MELANOTAN 2

Name: MELANOTAN 2
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MELANOTAN 2 • Pigmentation Research Peptide

Melanotan II is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH) and interacts with the body’s melanocortin receptor system. It was originally investigated for its ability to stimulate melanogenic activity, the biological process involved in producing melanin and skin pigmentation.

Early Phase I human research found that Melanotan II produced measurable increases in pigmentation in study participants. Researchers described tanning activity following a relatively small number of administered doses, making its effects on the melanocortin system an intriguing area of peptide research.

Interestingly, researchers also observed effects beyond pigmentation. Small placebo-controlled human studies subsequently investigated Melanotan II and the melanocortin system in relation to sexual arousal and erectile response. These studies reported significantly greater erectile activity with Melanotan II than placebo, along with increased sexual desire in some participants.

Research areas include: melanin production and pigmentation, melanocortin receptor activity, tanning response, appetite signalling, and sexual-function pathways.

Research note: Melanotan II remains an investigational peptide. Early studies were small, and reported adverse effects included nausea, fatigue, decreased appetite, yawning and flushing. Health Canada specifically lists Melanotan I and II among unauthorized injectable peptide products and warns that “research use only” labelling does not make such products authorized for human use.

MELANOTAN II | Research Overview
Melanotan II (MT-II) is a synthetic analogue of α-melanocyte-stimulating hormone (α-MSH) and an agonist of melanocortin receptors. Early human research demonstrated increased skin pigmentation, while broader experimental research has explored melanocortin signalling across pigmentation, neurobehavioral and social pathways.
Cognition + Neurobehavioral Research Emerging preclinical research has expanded interest in MT-II beyond pigmentation. In a 2023 zebrafish study, MT-II reversed high-fat-diet-associated impairments in recognition memory and changes in exploratory and anxiety-related behaviour. These findings are intriguing, but they are animal findings and do not establish cognitive benefits in humans.
Oxytocin + Social Learning Animal studies have also examined interactions between melanocortin signalling and the oxytocin system. Research in prairie voles found that MT-II influenced oxytocin-dependent neural activity associated with social learning and facilitated partner-preference formation. Again, these are preclinical findings and should not be interpreted as demonstrated effects in humans.
Research links: Human Phase I MT-II study | PubMedMemory & neurobehavior study | PubMedOxytocin & social-learning study | PubMedOxytocin-dependent partner-preference research | PubMed

MELANOTAN 2

MELANOTAN 2 • Pigmentation Research Peptide

Research and Scientific Studies