AOD-9604
AOD-9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone (hGH), specifically amino acids 177–191, with an additional tyrosine residue. It has been investigated primarily for its potential involvement in lipid metabolism and metabolic regulation.
Early laboratory and animal research explored AOD-9604 for its effects on lipolysis, the breakdown of stored fat, and lipogenesis, the process through which the body produces and stores fat. Researchers have investigated whether this fragment can influence metabolic pathways associated with adipose tissue without reproducing the broader growth-promoting effects associated with full-length growth hormone.
AOD-9604 has also been examined in preclinical and human studies related to obesity and weight management. While its biological activity has generated scientific interest, clinical research has not established AOD-9604 as an effective approved treatment for weight loss, and research findings should not be interpreted as evidence of therapeutic benefit.
Continued research is focused on better understanding its mechanisms, metabolic activity, safety profile, and potential applications within peptide and metabolic science.
For laboratory research purposes only. Not for human consumption.
Ng et al., 2000, Hormone Research: studied AOD-9604's metabolic actions in obese rats, including adipose-tissue lipolytic activity and insulin sensitivity.
Heffernan et al., 2001, International Journal of Obesity: examined AOD-9604 in obese mice, reporting increased fat oxidation and lipolysis and investigating whether those effects involved the hGH receptor.
Endocrinology study: investigated AOD-9604, lipid metabolism, and the role of beta-3 adrenergic receptors in mice.
Wilding, 2004: documents AOD-9604's development as a potential obesity treatment and that Phase IIa clinical trials had been underway.
